In Vitro and in Vivo Effects of Three Different Mitragyna Speciosa Korth Leaf Extracts on Phase Ii Drug...

In Vitro and in Vivo do of Three assorted Mitragyna speciosa Korth buckle Extracts on build II Drug Metabolizing EnzymesGlutathione Transferases (GSTs)Molecules 2010, 15, 432-441; doi:10.3390/molecules15010432 exposit ACCESS molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Article In Vitro and in Vivo Effects of Three contrastive Mitragyna speciosa Korth Leaf Extracts on Phase II Drug Metabolizing EnzymesGlutathione Transferases (GSTs) Juzaili Azizi 1, Sabariah Ismail 1,*, Mohd Nizam Mordi 1, Surash Ramanathan 1, Mohd Ikram Mohd distill 2 and Sharif Mahsufi Mansor 1 1 2 eye for Drug Research, Universiti Sains Malaysia, 11800 USM Penang, Malaysia School of chemical Sciences and Food Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia * Author to whom rest should be addressed; telecommunicate: sabaris@usm.my; Tel.: +60 46533269; Fax: +60 46568669. Received: 30 November cc9; in revised form: 2 January 2010 / Accepted: 7 January 2010 / scram: 20 January 2010 Abstract: In the present study, we investigate the excite of third different Mitragyna speciosa picks, videlicet methanolic, sedimentary and total alkaloid call downs, on glutathione transferase- limited activity in male Sprague Dawley rat colorful cytosol in vitro and in vivo.

In the in vitro study, the effect of Mitragyna speciosa distills (0.01 to 750 µg/mL) against the item activity of glutathione transferases was examined in rat liver cytosolic carve up from untreated rats. Our data put down concentration dependent quelling of cytosolic GSTs when Mitragyna speciosa extract was added into the reaction mixture. At the highest concentration used, the methanolic extract showed the highest GSTs specific activity inhibition (61%), followed by aqueous (50%) and total alkaloid extract (43%), respectively. In in vivo study, three different dosages; 50, 100 and 200 mg/kg for methanolic and aqueous extracts and 5, 10 and 20 mg/kg for total alkaloid extract were given...If you want to get a enough essay, order it on our website: Orderessay

If you want to get a full information about our service, visit our page: How it works.